Chemistry Services
Medicinal Chemistry
Our medicinal chemistry team supports hit-to-lead and lead optimization programs through rational design, SAR-driven synthesis, scaffold optimization, impurity understanding, and physicochemical property enhancement. We work closely with clients to accelerate candidate progression with a strong focus on quality, speed, and scientific insight.
- Hit to lead optimization for improving potency and toxicity profiles
- Focused compound libraries
- Scaffold and metaboilite synthesis
- Prodrugs/Bioisosteres
- Large scale synthesis of lead compounds
Our core expertise is centered around advancing drug discovery programs through integrated medicinal chemistry and innovative synthetic solutions, including:
Synthesis of focused and target-oriented compound libraries for discovery programs
Hit-to-lead and lead optimization support to improve potency, selectivity, ADME, and safety profiles
Synthesis of metabolites and specialized reference standards
Development of novel, efficient, and scalable synthetic routes for complex molecules
Synthesis of prodrugs, scaffold-modified analogs, and bioisosteric compounds
Medicinal chemistry support for SAR exploration and molecular optimization
Custom synthesis solutions for early-stage drug discovery and research applications
Route scouting and process feasibility evaluation for synthetic optimization
Integrated Discovery-to-Scale Platform
The Aral + Khodiyar integrated model seamlessly connects scientific project execution with large-scale GMP manufacturing — from first hit to commercial API supply.
Integrated Chemistry Flow :
- Hit-to-Lead
- Medicinal Chemistry
- Route Scouting
- Process Development
- Pilot Scale
- Kg Manufacturing
- GMP Supply
Custom Synthesis Services
We provide custom synthesis support ranging from milligram to kilogram scale for research, discovery, and process development applications. Recognizing that laboratory-scale procedures are often not directly scalable, our scientists develop practical, efficient, and reproducible synthetic strategies optimized for yield, purity, cost, and scalability.
Our custom synthesis capabilities include:
- Multi-step organic synthesis of small molecules and advanced intermediates
- Synthesis of novel scaffolds, analogs, metabolites, impurities, and reference compounds
- Route scouting, route optimization, and process feasibility evaluation
- Scalable synthetic solutions from mg to kg quantities
- Development of robust and reproducible synthetic procedures
- Rapid problem-solving for complex synthetic challenges
- High-quality analytical characterization and documentation support
Focused Library Synthesis
Our focused library synthesis platform is designed to accelerate hit discovery, hit expansion, and lead optimization programs through the rapid generation of high-quality compound libraries. With strong expertise in medicinal chemistry and parallel synthesis approaches, we efficiently design and synthesize structurally diverse and target-oriented libraries aligned with client screening objectives.
Our focused library services include:
Large Scale Manufacturing Capability
- Design and synthesis of focused libraries for hit identification and hit-to-lead programs
- Diversity-oriented and SAR-driven compound library generation
- Rapid validation and optimization of synthetic routes for library production
- Synthesis of scaffold-based analog series at discovery scale
- Efficient production and purification workflows for high-throughput delivery
- Compound management solutions aligned with screening and assay requirements
- Individual compound tracking using unique coding and data management systems
- Flexible packaging, shipment coordination, and global logistics support
Science ✦ Research ✦ Innovation ✦ Chemistry ✦
Our Testimonials
