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Purity Enrichment Services: Enhancing the Quality and Safety of Chemical Compounds

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Detailed analysis of chemical compositions provides valuable information. This allows chemical problem-solving, supports R&D efforts, and most importantly, enhances the quality and safety of the chemical formulation of products. Purity enrichment analysis is the application of various analytical techniques to get detailed data on the chemical structure and concentration of the components in the sample of interest. This helps in product development, the concentration of specific components like APIs that impart a specific function to the product, and solving manufacturing problems. With Aral Research, you can be confident in the quality and safety of your chemical compounds.

Purity Enrichment for Chemical Compounds

Purity enrichment plays a crucial role in different stages of research and development in chemical development. It involves the identification and isolation of unknown materials in chemicals, polymers, packaging, and other materials. To ensure the quality and safety of chemical compounds, various analytical techniques like gas or liquid chromatography, mass spectrometry, preparative LCMS, and other methods are used. Aral Research has a broad spectrum of analytical services to characterize unknowns and impurities to produce reliable results. We employ gas chromatography, mass analysis, and purity by HPLC in Ahmedabad to detect irregularities, trace levels, and impurities in our state-of-the-art laboratory.

Purity Enrichment for Diverse Chemical Compounds

  • Agrochemicals & Pesticides: These chemical-based products play a pivotal role in global food production; however, regulatory hurdles can lead to market delays. We employ advanced analytical services like impurity screening by LCMS to achieve a well-characterized product.
  • Basic & Industrial Chemicals: Chemical raw materials from petrochemicals, basic organics, and intermediaries for chemical processes need to comply with quality and regulatory standards. We can assist you in quality control testing and impurity analysis and guide you through the process.
  • Speciality Chemicals: Speciality chemicals or performance chemicals are used as an ingredient in the final product to improve the manufacturing process. Our team tests the chemical composition and physical properties of your speciality chemicals to meet and exceed quality and safety and ensure optimal performance characteristics.
  • Pharmaceutical Chemicals: We provide analytical services for API, NCEs, and drug product formulations that can affect the final stability and shelf life of medical compounds.

The presence of impurities and unknown components at even trace levels can impact the final product. Aral Research, with its years of experience and commitment to excellence, can assist you with purity enrichment to identify the impurities and unknown components. Our team is adept at solving the toughest and most challenging analytical problems. Our lab is equipped with the most advanced instruments for mass analysis, lyophilisation, and HPLC service in Ahmedabad. We employ proven methodologies to efficiently isolate and identify a component to determine the source of impurity. To discuss your research and analysis requirements, call us today.

Visit Today:- How is HPLC Used in the Medical Sector?

How Lyophilization Enhances Vaccine Stability and Distribution

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Highly successful vaccines induce specific immune responses and protect against deadly viral diseases. One of the major challenges of human and livestock vaccines is vaccine stability due to infectivity and antigenicity. Vaccine formulations are subject to instability due to degradation through physical and chemical pathways. Lyophilization enhances vaccine stability and distribution. It helps to maintain vaccine stability and supports cold chain transportation that requires  2 degrees Celsius to -8 degrees Celsius. 

Lyophilization To Enhance Vaccine Stability and Distribution

Lyophilization, also known as freeze-drying, plays a crucial role in the vaccine industry. It is used to manufacture vaccines composed of lyophilized proteins and adjuvants while maintaining optimal potency. Once the vaccines are lyophilized, they remain stable even at higher temperatures, such as 40 degrees Celsius, for an extended period. This eliminates the need to worry about maintaining vaccine stability at higher temperatures, reduces the loss of vaccine activity, and controls the economic cost of vaccine production and distribution, which are major challenges faced by the vaccine industry. Aral Research offers exceptional lyophilisation services in Ahmedabad for your product formulations, API, drugs, and other compounds. If you are considering lyophilizing your product, we are here to help. 

How Are Vaccines Lyophillized? 

Lyophilization or freeze-drying is a method for drying vaccines. It consists of three steps:

  • Freezing, where the liquid is converted to ice.
  • Primary drying, where the ice is removed through sublimation.
  • Secondary drying, where the residual water is removed through desorption.

Lyophilization allows drying without destabilizing temperatures that could damage the antigens. Moreover, this process operates as an aseptic process, allowing the final product to meet stringent pharmaceutical standards and regulations. 

Lypholilization in the Pharmaceutical Industry 

Lyophilization is a crucial process in the pharmaceutical industry, especially for preserving sensitive drugs that cannot be produced by traditional techniques. Pharmaceutical companies use this method to lyophilize eye drops, injections, and other delicate drugs. In the biopharmaceutical sector, it is used to preserve proteins and peptides for long-term storage, providing unstable biologics with a longer shelf life and stability for wider distribution. 

Aral Research: Your Trusted Partner for Lyophilization

Aral Research is one of the most trusted HPLC testing labs in Ahmedabad, offering exceptional lyophilization services. With a proven track record of working within the industry from simple to complex drug formulation, we are your trusted partner for lyophilization. We manage the entire process, from formulation to final product, ensuring your product is lyophilized, packed, and shipped as per your specifications. To partner with us for lyophilization, call us. 

Read Now:- The Science Behind Lyophilisation: How It Preserves Your Products?

5 Common Misconceptions about Mass Spectrometry

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Mass spectrometry, a powerful tool in scientific research, plays a pivotal role in identifying the mass-to-charge ratio. It is a widely accepted research technique in various sectors, including forensic science, pharmaceuticals, metabolomics, clinical research, life sciences, and more. Despite its proven benefits, some researchers remain sceptical of mass analysis due to preconceived notions that have caused certain misconceptions about mass spectrometry. In this article, we aim to debunk these misconceptions and highlight the numerous advantages of mass spectrometry. 

Debunking 5 Common Misconceptions about Mass Spectrometry

Misconception 1: “Mass Spectrometry is Too Complicated”

Many analytical labs have concerns related to mass spectrometry as they think it is too complicated to work with. Although the process of ionization, acceleration, deflection, and detection can be challenging, mass spectrometers take care of all of these. Undoubtedly, mass analysis is one of the most effective and user-friendly analytical methods. The staff only needs to put the sample into the equipment. 

Misconception 2: “Mass Spectrometry Needs Too Much Space”

Analytical labs may have limited space, but the latest mass spectrometers are compact and designed to make the most of the space without impacting data integrity. At Aral Research, our mass analysis in Ahmedabad uses top-notch mass spectrometers for their high-resolution capabilities, compactness, and ability to handle complex samples without taking up much space. We help clients with their research that can be done with mass spectrometry, offering a new perspective on hypotheses.  

Misconception 3: “Mass Spectrometry is Too Expensive” 

Researchers and labs often have a notion that mass spectrometry is expensive and the process is too slow. However, this is a misconception. In reality, mass spectrometers are highly effective and cater to complex research demands, making them a valuable investment. With mass spectrometry, researchers benefit from automation and optimization that is more efficient than affinity-based assays. With more data collected at the same costs, traditional analytical methods make MS analysis more economical, providing a high return on investment. 

Misconception 4: “Mass Analysis Takes Too Long”

Assays need separate kits for the analysis of multiple samples. Advancements in mass technology, like the shift from data-dependent acquisition (DDA) to data-independent acquisition (DIA) techniques, improve the signals from less abundant molecules to enhance the amount of data collected from each sample. MS analysis is now scaling rapidly with enhancements in workflows, automation, and parallelization. At Aral Research, our analytical testing laboratory, we have extensive experience in large-scale analysis empowering large-scale studies, research, and discovery & drug development.  

Misconception 5: “ GC-MS/MS Works Just Fine”

Many labs use mass spectrometry but are hesitant to move from GC-MS to LC-MS/MS. Though there is absolutely no problem with that, gas chromatography is a complex sample prep method and is labour-intensive. This can add costs and restrict testing to a finite amount of compounds. LCMS analysis in Ahmedabad supports more extensive molecule testing, offering greater capabilities for classifying analytes in different compounds in a single run. 

It is time to transition to mass spectrometry as a part of routine compound testing and analysis. From verifying and validating biomarkers to enhancing the identification of unknown compounds and the discovery of new drug candidates, mass spectrometry plays a pivotal role. If you need analytical support for your research, we’re here to help. Call us today to learn more about how mass spectrometry can benefit your work. 

Visit:- Application of NMR Spectroscopy

Mass Spectrometry for Protein Analysis

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Mass spectrometry (MS) is a primary analytical method for protein research and the study of biomolecules. Mass analysis of proteins measures ions’ mass-to-charge (m/z) ratio to identify and quantify molecules in simple to complex mixtures. The development of high-throughput mass analysis has made this analytical method profound across different fields, particularly proteomics. This further expanded research related to protein structure, function, modification, and dynamics. 

What is Protein Mass Spectrometry? 

Proteomics is the study of proteins in biological systems such as tissues, cells, or organisms. Technological advancements in mass spectrometry have helped open horizons related to proteomics. Protein mass spectrometry is the use of mass spectrometry in studying and characterizing proteins, comprising quantification, interaction mapping, profiling, and identification of post-translational modifications. Aral Research provides mass analysis in Ahmedabad backed with a WATERS SDQ detector and TQD detector equipped with Electrospray Ionization (ESI) and Atmospheric-pressure Chemical Ionization (APCI), enhancing MS capabilities. 

Application of Mass Spectrometry for Protein Analysis

  • Identification and verification of proteins.
  • Determining protein structure, function, folding & interactions.
  • Identification of protein from the mass of its peptide fragments. 
  • Quantitate proteins (absolute or relative) in a given sample of interest.
  • Evaluate enzyme reactions, protein digestion and chemical modification. 

MS Workflow for Protein Complex Research 

  • AQUA Strategy: The Absolute Quantification of Ubiquitination (AQUA) strategy involves developing synthetic heavy peptides that demonstrate ubiquitination linkages. The peptides are blended with the concentration of sample peptides and analyzed by mass spectrometry. 
  • Labelling of Protein Extracts: Proteins from different cell lines are individually labelled with isobaric labels. Following the breakdown, the peptides from every sample are combined and analyzed by MS, allowing for every sample’s peptides to have a similar mass-to-charge ratio. 
  • Independent Examinations: Samples are evaluated independently, and the cell lysate extracts the needed protein complex with affinity purification. Following digestion, the complex is examined using mass analysis to determine its components. 

Protein Mass Spectrometry at Aral Research 

Our mass analysis, coupled with HPLC service in Ahmedabad, aims to empower researchers with precise and reliable data with state-of-the-art techniques and equipment to characterize biomolecules, emphasizing proteins and peptides, metabolites, lipids and small molecules mass spectrometry. Backed with ESI and APCI, we assure precision and high-quality analytical data for your diverse requirements. Call us to discuss your analytical needs. 

HPLC Role in Pharmaceutical Analysis

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High-performance Liquid Chromatography (HPLC) is an incredible analytical method with a broad range of applications across different industries. With its flexibility and performance, HPLC is employed in various pharmaceutical applications, research, and clinical laboratories. HPLC plays a pivotal role in the separation and analysis of pharmaceutical raw materials and drugs.  It is an essential tool in pharmaceutical applications like purity analysis and evaluating formulations. In this blog, we discuss the view of HPLC’s role in pharmaceutical analysis. 

High-Performance Liquid Chromatography (HPLC) in Pharmaceutical Analysis

There are various methods for analyzing pharmaceutical compounds, and HPLC is the best choice for the analysis of these compounds. HPLC has become a standard practice in the pharmaceutical industry for various samples. It is used to check the purity of new drug candidates, conduct in-process testing for developing new formulations, track changes or the scale-up of synthetic procedures, and control the quality of final drug products. HPLC is also used to analyze many natural products, plant extracts, and herbal medicines. Aral Research is a trusted HPLC lab test in Ahmedabad for pharmaceutical analysis. Our HPLC testing lab is equipped with the latest advanced instruments for reliable results and the lowest turnaround time. 

How is HPLC Used for Pharmaceutical Analysis? 

High-performance Liquid Chromatography (HPLC) is renowned for its precision and accuracy. Despite its high costs, HPLC is an ideal method for the accurate identification and quantification needed for pharmaceuticals. HPLC is used to analyze pharmaceutical products such as drugs and medicines for the ingredients they contain. It is employed to separate, quantify, and identify different components along with their quantities. This allows manufacturers to get valuable insights into the drug properties and how each component’s quantities impact the overall performance and strength of the product. Moreover, it also allows us to identify and quantify any impurities within the pharmaceutical products. 

HPLC Pharmaceutical Applications: 

  • Determination of shelf life of drugs and pharmaceuticals. 
  • Identification of active ingredients 
  • Tablet dissolution of pharmaceutical dosage forms
  • Pharmaceutical quality control 

The process of creating a new pharmaceutical drug can be divided into 3 main stages: 

  • Drug discovery
  • Drug development
  • Drug manufacturing 

HPLC plays a pivotal role in all these stages, including applications such as separation and quantification of different analytes through analytical HPLC or isolation & purification of compounds through preparative HPLC.  Aral Research is one of the most trusted HPLC testing labs in Ahmedabad, offering exceptional services for the pharmaceutical industry in the identification and isolation of active ingredients, quality control of raw material formulations and determination of the shelf life of finished products. This comprehensive application of HPLC ensures that all aspects of drug creation are thoroughly monitored and controlled. To discuss your analytical requirements, call us today.

LCMS in Small Molecule Drug Development

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With the constantly evolving technology, mass spectrometry (MS) coupled with high-performance liquid chromatography (HPLC) has become a standard practice used for drug development. LCMS is used to support small molecule drug development, such as impurity, degradant structure characterization, and qualification and quantification analysis. 

LCMS for Drug Impurity Identification & Profiling 

Impurity identification and profiling, crucial for ensuring the safety and efficacy of drug development and active pharmaceutical ingredients (APIs), are made possible with LCMS. Regulatory bodies have set stringent guidelines for identifying impurities at low levels, and LCMS analysis in Ahmedabad is recommended for small molecule drug development due to its reliability and efficiency. LCMS not only helps comply with these guidelines but also optimizes drug product development processes, providing a secure foundation for drug development. 

LCMS  in Small Molecule Drug Development

LCMS, with its combination of LC and MS, has become the preferred analytical method for its superior sensitivity and selectivity in pharmaceuticals. The efficiency of LCMS, achieved through continuous improvement in LC and MS, has made it prevalent in small molecule quantitation analysis. Aral Research provides LCMS service in Ahmedabad with High-efficiency UPHLC, allowing significant peak capacity improvements and shorter run times, ensuring both speed and accuracy in drug development. 

The uniqueness of LCMS lies in its combined high resolving power of HPLC and superior mass analysis. It provides a solution to different structural characteristics in pharmaceutical research. This includes identifying trace levels of impurities and degradants in bulk drug substances, and most importantly, identifying metabolites in drug metabolism studies. LCMS plays a crucial role in identifying unknowns in synthetic reaction products. The most crucial aspect of pharmaceutical development is the identification of impurities in bulk drug substances. LCMS not only addresses concerns relating to relevant regulatory issues but also optimizes scale-up processes to maximize yield. The impurity content of 0.01% or above in API represents low picomoles of material in HPLC assay that need to be characterized. The use of LCMS can offer structural information on unknown impurities in production batches.

With the advancement in ionization techniques and instrumentation, liquid chromatography-mass spectrometry has become a powerful technology for the characterization of small molecules and proteins. At Aral Research, our HPLC testing labs in Ahmedabad emphasize high-throughput LCMS analysis, structural analysis of trace levels of impurities in drug substances, identification of metabolites and characterization for product improvements. 

Difference Between Liquid Chromatography & Gas Chromatography

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Chromatography is the process of separating and identifying compounds from a sample of interest. It is an indispensable tool for isolation and purification of compounds. Chromatography is classified based on the physical state of the mobile used: Liquid and gas chromatography. How are these two chromatography methods different? Let’s find out!

What is Liquid Chromatography? 

Liquid chromatography is a separation method that is used in labs to separate sample mixtures based on the interaction between the individual molecules. The HPLC lab test in Ahmedabad uses this technique in the liquid mobile phase, where the sample mixture is blended with liquid. It is allowed to pass through a column filled with the stationary phase or a solid sheet of the stationary phase. The liquid chromatography method separates and analyzes high thermal stability and non-volatile and challenging vapourization. It is extensively used for quantitative analysis of pharmaceutical products and laboratories.

What is Gas Chromatography? 

Gas chromatography is another chromatography technique that analyzes volatile samples, which are gases at room temperature, and a gaseous mobile phase that carries the sample through a solid phase. The sample flows through the gas system, which is gasified before entering the chromatographic column with a filler for effective separation. 

Difference Between Liquid Chromatography & Gas Chromatography

  • Mobile Phase Used: The primary difference between HPLC and GC is the mobile phase used. LC uses a solvent for the mobile phase in which the compounds’ polarity, complexity, and solubility determine the solvent to be used. Meanwhile, GC uses an inert or unreactive gas. 
  • Separation Methods: For the HPLC service in Ahmedabad, the separation of the compounds is determined by the interaction between every compound in the mixture in the mobile and stationary phases. In gas chromatography, the separation depends on the respective volatility of every compound in the mixture. 
  • Temperature: Due to the volatility of the sample, gas chromatography needs to be done at higher temperatures than high-performance liquid chromatography. The column temperature of GC is somewhere between 150 to 300 degrees Celsius, while for HPLC, it is done at room temperature. 
  • Difference in Applications: Gas chromatography is typically used to measure oils, air samples, organic compounds, and pharmaceutical drugs. While HPLC for inorganic ions, proteins, peptides, lipids and vitamins. 

It is crucial to know the difference between liquid and gas chromatography so you can select the most appropriate method for the sample. Apart from choosing the right method, achieving accurate results during analysis is essential, which Aral Research can help you. We offer a broad range of analytical services, including UHPLC, HPLC, mass analysis, purity enrichment, LCMS analysis services, and more. To know more about analytical services, call us today.  

Unlocking the Power of Mass Analysis: Key Benefits for Modern Research

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Modern research demands powerful and efficient analytical techniques and methods to delve into the deeper and intricate aspects of compounds. Mass analysis is a cutting-edge analytical method that has revolutionized the field of research, enabling researchers and scientists to get invaluable insights into molecular weight, structural characteristics, and analysis. So, let’s explore the key benefits of mass analysis in modern research, emphasizing its importance in various scientific fields.

Understanding Mass Analysis

Mass analysis or mass spectrometry is a powerful analytical method that measures the mass-to-charge ratio (m/z) of ions to identify and quantify molecules. This analytical method involves the ionization of analytes and separation based on the mass-to-charge ratio utilizing the mass analyzer. In recent years, MS analysis has been employed to discover new molecules and determine quantities of known components and structural & chemical properties of molecules in industries such as pharmaceutical, chemical, biotechnology, food & beverages, and the life science industry. Aral Research offers impeccable mass analysis in Ahmedabad. Our MS spectrometry solutions are designed to deliver precise results, high-quality data, analytical flexibility, and real impact on your research.

Benefits of Mass Analysis for Modern Research

  • High Sensitivity & Precision

Mass spectrometry is utilized to determine the structural aspects of molecules, helpful for researchers working on environmental, metabolomics, and proteomics. It is used to examine the molecular weight, elemental content of chemicals, and fragmentation of patterns. These valuable insights are very helpful in understanding the structure of biomolecules and chemical reactions. Moreover, mass analysis is also used for the identification of proteins, lipids, and peptides.

  • Quantitative Analysis

Another advantage of mass spectrometry is that it can be used for qualitative analysis to determine the concentration of particular compounds in a sample of interest. This helps in encompassing nature’s biological process and variations within the metabolite formations.

  • Highly Versatile

Mass analysis is a versatile analytical method that can be applied in different fields. It finds applications in fields such as biochemistry, chemistry, forensics, pharmaceutical, clinical research, life science, and environmental science. Mass spectrometry has become an indispensable tool in modern research disciplines as it can analyze all types of molecules.

  • Integration with Latest Technology

The emergence of more advanced and powerful mass spectrometers has expanded the capabilities is mass analysis. It provides a more enhanced sensitivity, precision, and quick analysis. Analytical techniques like gas chromatology and ion mobility integration with mass analysis have made this analytical technique more versatile and robust.

Mass analysis is an indispensable tool for the analysis of a range of range samples, providing insights into the structure, concentration, isotopic distribution, and biological molecules in the sample. Aral Research also provides LCMS analysis in Ahmedabad for high sensitization quantification and qualitative workflow for research and development. LCMS integrates the power of mass spectrometry and liquid chromatography, providing more comprehensive data. For more details on mass analysis services, call us today.

Visit:- How can Mass Spectrometry be used to Identify Unknown Compounds?

The Science Behind LCMS Analysis: Enhancing Sensitivity and Specificity

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Liquid chromatography with mass spectrometry (LCMS) is a simple yet efficient technique for measuring analytes in biological matrices with high sensitivity and specificity. It plays a pivotal role in biomedical research, pharmaceuticals, environmental testing, and biotechnology. This powerful technique integrates liquid chromatography’s physical separation capabilities with mass spectrometry analytical excellence. LCMS is used to analyze various types of compounds, organic molecules, and large biomolecules. In this blog, we understand the science behind LCMS analysis, shedding light on its significance in different research & life science fields.

Understanding Liquid Chromatography Mass Spectrometry (LCMS)

Liquid chromatography and mass spectrometry are powerful techniques for analyzing complex mixtures, offering enhanced sensitivity and specificity in analysis. The term ‘sensitivity’ in LCMS refers to a change in signal per unit change in concentration of an analyte. It describes how the LCMS instrument can detect the relationship between the concentration of an analyte and the signal given. The field of LCMS has seen significant advancements, with advanced techniques improving the capabilities of LCMS, providing enhanced sensitivity and accuracy. Aral Research offers LCMS analysis in Ahmedabad with hands-on experience in working with clients from different fields.

The Science Behind LCMS: How Does LCMS Analysis Work?

Liquid Chromatography Components:

  • Mobile Phase: LC involves the physical separation of analytes in a sample of interest. A solvent carries the sample that is chosen based on the sample’s characteristics.
  • Stationary Phase: The substances in the column interact with components of the sample, helping the separation.
  • Flow Rates: The speed of the mobile phase travels via the column is important for controlling resolution time and resolution.

Mass Spectrometry Components:

  • Ion Souce: The ion source is vital for mass spectrometry for the ionization of molecules before they enter the mass analyzer. This process transforms the neutral molecules into ions to make them amenable to MS spectrometry.
  • Mass Analyzers: Different types of mass analyzers are available, providing different mass resolutions and accuracy capabilities. Quadrupole analyzers are used for routine analysis, while Time-of-Flight analyzers are used for high-resolution mass analysis.
  • Detectors: They convert physical signals from the ions into electrical signals, which are processed to give valuable data. They are vital for quantification and identification of analyzed compounds.

Working Principle Of LCMS

In liquid chromatography, the sample is dissolved in a solvent or mobile phase that passes through a column packed with a stationary phase. The sample components interact with the stationary phase for separation. It is crucial to note that factors like flow rates, solvent composition, and the properties of the stationary phase impact the process.

After separation by liquid chromatography, the compounds enter mass spectrometry to be ionized via methods like Atmospheric Pressure Chemical Ionization (APCI) and Electrospray Ionization (ESI). The ions are detected and sorted according to their mass-to-charge ratio (m/z) for the identification and quantification of compounds, offering a detailed view of the sample.

The combination of LC and MS offers a powerful technique for analyzing complex mixtures, offering accuracy, high sensitivity, and specificity. Aral Research, a leader in the field, offers high-quality LCMS service in Ahmedabad backed with SQ detectors for high-quality data. Our LCMS has gained immense prominence in fields like pharmaceutical, biotechnology, chemical analysis, and nutraceuticals. To discuss your project research details, call us today and experience the quality service we provide.

Checkout Now:- Advancements in LCMS Technology: Transforming Pharmaceutical Analysis

Importance of Purity Enrichment Services in Product Development

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Quantification, characterization, and control of impurities are key parameters in product development in terms of pharmaceutical or drug products. Impurities are unwanted chemicals that stain in active pharmaceutical ingredients (API) or drug formulations. The impurities can arise during synthesis or from sources like raw materials, solvents, reagents, intermediaries, reaction by-products, or catalysts. The amount of impurities found in these products determines the safety of the final products. This is why purity enrichment is crucial in the product development stage.

Impurity Identification & Characterization

During the product development stage, unknown compounds can arise from impurities that can be formed in the manufacturing or storage. Regularity bodies require identification of the impurities present in the new drug’s substance and characterize their structure. At Aral Research, we have expertise in analyzing impurities, API, and metabolites in products across different modalities. We offer NMR, gas chromatography, HPLC, high-resolution mass spectrometry, and LCMS analysis in Ahmedabad. Our team serves as your extended team to offer customized purity enrichment in accordance with the FDA, CDSCO, EMA, and other regulatory bodies. Our commitment further extends to our dedicated expertise in analyzing drugs and products for clinical trial support. With our proven techniques and well-established labs, we efficiently evaluate the efficacy and safety of your products.

Types of Impurities

  • Organic Impurities: These are found during drug manufacturing or storage.
  • Inorganic Impurities: These are found in drug manufacturing, including reagents, inorganic salts, heavy metals, or catalysts.
  • Residential Solvents: These are introduced in the preparation stage.

Our Purity Enrichment Solutions Include:

  • Nuclear Magnetic Resonance (NMR)

Some unknown impurities are difficult to quantify and characterize. Our NMR analysis in Ahmedabad is a powerful analytical technique for structural elucidation of unknown purities. It determines how the atoms of a specific molecule are interconnected, hence determining purity.

  • Gas Chromatography

GC is used to assess the residential solvent impurities of API or drug products, drug samples, toxicological testing, VOCs, food & beverages, cosmetics, and odorous compounds.

  • High Ultra Performance Liquid Chromatography and Liquid Chromatography Mass Spectrometry (HPLC/UPLC & LCMS)

The HPLC/UPLC techniques are of profound significance in evaluating impurity profiles and quantification of impurities for API and drug products. Impurity analysis is performed by HLPC with mass analysis, and UV detects and measures all impurities in a sample and offers more efficient and precise results. Moreover, technologies like UPLC provide major enhancements in throughputs and sensitivity, benefiting the process of product release and identification of drug-related impurities.

  • High-Resolution Mass Spectrometry

High-resolution mass analysis provides an orthogonal perspective to structural data evaluation in terms of unknown impurity characterization. Mass spectrometry offers precise mass data that is resolved for the computation of the molecular composition of unknown impurities.

Aral Research offers comprehensive support in the identification and quantification of impurities in drug substances and pharmaceutical products. We are a full-fledged research laboratory that specializes in supporting product development, including analytical, drug, and impurity characterization. We provide exceptional analytical solutions for our client’s research and development challenges and tailor these solutions to align with their needs. To know more about analytical services, call us today.

Read Now:- Why do purity enrichment services matter in Pharmaceutical Manufacturing?

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