NUCLEAR MAGNETIC RESONANCE SERVICES
NMR Services
Aral Research specialises in delivering high-quality and customised research services tailored for pharmaceutical and life sciences researchers. Nuclear Magnetic Resonance (NMR) is a pivotal analytical method extensively employed in drug discovery and development. It plays a crucial role in exploring protein-protein interactions, conducting small-molecule screenings, and assessing bioequivalence.
NMR analysis provides comprehensive molecular data essential for understanding chemical composition, structural intricacies, morphology, and dynamics. This analytical technique is indispensable for the unambiguous identification of both known and novel compounds in pharmaceutical research.
NMR exploits the property of atomic nuclei, specifically their nuclear spin (I), to resonate when exposed to a strong magnetic field and a weak oscillating magnetic field at radio frequencies. This resonance generates an electromagnetic signal with a frequency characteristic of the nucleus’s magnetic environment. NMR is particularly effective for nuclei such as 1H, 13C, 15N, 19F, among others.
At Aral Research, we offer specialised NMR analysis services to empower clients in the pharmaceutical industry. Our services deepen insights into molecular interactions and binding mechanisms of drug candidates. We verify the purity and composition of compounds critical for drug formulation. Additionally, we assess the quality and consistency of drug candidates throughout the drug development lifecycle, ensuring robust and reliable pharmaceutical products.”
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Nuclear Magnetic Resonance Services Supporting Pharma, Biological & Chemical Research
Nuclear Magnetic Resonance Analysis by Aral Research
NMR is an analytical biophysical technique used to study molecular structures. This is done by studying how a single nucleus responds to a strong magnetic field. The ligand-based and protein-based approaches allow us to observe chemical compounds and target biomolecules. Our NRM services are valuable in drug discovery, understanding molecular interactions, and studying the dynamics of biological systems. Our experienced NMR team is well-versed in No-D NMR analysis and advanced analytical techniques.
Our NMR spectroscopy offers a wealth of information to support pharmaceutical and biopharmaceutical applications. It provides detailed molecular structure information to help clients confirm and determine the identification of pharmaceutical substances and impurities. Additionally, it can give vital information about the higher-order structure of biologics like biosimilars and proteins.
Why Choose Our NMR Analysis Services?
1D Heteronuclear Experiments
Aral Research performs 1D heteronuclear experiments, enabling precise analysis of nuclei such as 1H, 13C, 15N, 31P, 19F, and other hypernuclei.
Quantitative NMR (Q-NMR)
We excel in Quantitative NMR (Q-NMR) analysis, providing precise and accurate quantification of compounds. Our expertise ensures reliable results for a wide range of applications, including purity assessment, concentration determination, and quality control.
Identification of Impurities & Unknowns
We specialize in identifying impurities and unknown compounds with precision. Utilizing advanced analytical techniques, we ensure accurate detection and characterization, supporting quality control and regulatory compliance in various industries.
Determination of Lipid-to-Protein (L/P) Ratio
The precise determination of lipid-to-protein ratios, employing advanced analytical techniques. Our methods offer critical insights into the compositional balance between lipids and proteins within biological samples. This analysis supports comprehensive research and development efforts by elucidating molecular interactions and structural dynamics crucial for understanding biological processes.
Ligand-Observed NMR
We specialize in Ligand-Observed NMR techniques, providing detailed insights into ligand binding and interactions. Our advanced methods ensure accurate analysis, supporting drug discovery, and molecular interaction studies.
Advanced 1D and 2D Analysis
Advanced 1D experiments such as NOE, and a range of advanced 2D experiments including COSY, TOCSY, HSQC, HMBC, NOESY, ROESY, DOSY, and more.
High Resolution & Highly Sensitive NMR
This method offers high sensitivity to a wide range of pharmaceutical analysis applications. Its highly sensitive service allows trace analysis and identification of low-level impurities and residuals.
No-D NMR
No-Deuterium Proton NMR is a method to measure high-resolution 1H NMR spectra without using deuterium solvent. In the No-D NMR, various reaction mixtures or reagent solutions are directly available with the help of protonated solvents.
End Cap Analysis
We provide advanced end cap analysis, utilizing specialized techniques to provide detailed insights into the composition and structure of end caps in materials. Our precise methodologies offer critical data on end cap functionality, compatibility, and performance, supporting comprehensive research and development efforts in various industries.
Protein-Observed NMR
This method directly studies proteins and offers detailed information on their structure, dynamics, and interaction. It is used to observe the changes in proteins and dynamics after binding with a ligand. This is important for understanding the mechanism of action of a drug candidate.
Have any questions?
Frequently Asked Questions
Nuclear Magnetic Resonance (NMR) is a critical analytical method for elucidating the structure of various materials, from small molecules to compounds. It is extensively used for analyzing pharmaceuticals, screening weak binding compounds, drug discovery, and identification of pharmaceutical substances and impurities.
The NMR method is used to analyse various samples, including small organic molecules, biomolecules, and complex mixtures.
Nuclear Magnetic Resonance can offer detailed information related to dynamic processes, molecular structure, chemical environment and molecular interactions.
Nuclear Magnetic Resonance (NMR) plays a pivotal role in the pharmaceutical structure confirmation of impurities and APIs. Additionally, it is used for pharmacology testing of excipients and raw ingredients. NMR analysis is employed throughout a drug product's lifecycle, from the discovery stage to routine quality control testing.
NMR offers a detailed overview of organic components with a sample. The preparation and experiment time is quicker, so a great deal of information can be obtained quickly. It offers qualitative and quantitative information over different sample matrices.
The working principle of NMR is based on the nuclei of an atom absorbing electromagnetic radiation in the radio frequency region of 4 to 900 MHz. It depends on the interaction between nuclear spin and the external magnetic field.
The costs of NMR analysis depend on the NMR experiment, sample preparation, and data interpretation services. Contact Aral Research for a detailed quote.
What our client have to say
Testimonials
Aral Research committed to providing with the highest level of service and qualitative analytical data to our client. Our team of experts takes pride in staying up to date with the latest techniques and methodologies, and we are dedicated to providing innovative and efficient analytical solutions to meet your research needs.
ARAL RESEARCH provide qualitative analytical data with proper interpretation to help you with your research needs. We specialize in characterization reports that utilize various analytical techniques such as Mass, LCMS, HPLC, and NMR. We are proud to offer customized reports tailored to your specific research requirements.
