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NMR Services Demystified: How It Works and Its Critical Applications

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Nuclear Magnetic Resonance Spectroscopy (NMR) is an innovative method for determining atoms’ chemical and physical properties. It detects the energy absorbed when the nuclei in the magnetic field are exposed to a radiofrequency pulse. The basic working principle of NMR is grounded in the quantum mechanics and magnetic properties of specific atomic nuclei.

Understanding the NMR Magnetic Resonance Principles

Understanding the principles of NMR reveals the profound significance of the alignment of nuclear spins in the magnetic field. Nuclei with a positive spin state have lower energy than those aligned on the opposite side. A radio frequency pulse is applied that matches the energy difference between the two states, which causes the nucleus to flip to spin. The frequency needed to cause this transition is the ‘resonance frequency’ that is specific to every type of nucleus in the magnetic field. After the absorption, the nuclei revert to their lower energy state known as ‘relaxation’. In this process of ‘relaxation’, the energy emitted is detected and transferred into the NMR spectrum, providing valuable details about the molecular structure of the sample of interest. Aral Research offers expert Nuclear Magnetic Resonance Service in Ahmedabad to provide clients with quality analysis with quick turnaround times.

The Science Behind NMR

The working principle of nuclear magnetic resonance, blended chemistry, and physics is used to provide data on molecular composition. It starts with the placement of the sample of interest in a strong magnetic field to create a solid and uniform magnetic field. The beginning alignment of the nuclear spin is disrupted by transmitting radio waves at a specific frequency. This disruption provides an energy transition that is detected in the form of NMR signals after the radio frequency pulse is switched off. With the application of ‘The Fourier Transform’, the NMR signals that are time-reliant are converted into frequency-domain spectra that display the resonance frequencies of the nuclei to provide valuable insights into the molecular structure of the sample.

Choose Aral Research for Reliable NMR Services

Aral Research offers NMR service in Ahmedabad to provide analytical data to diverse sectors. We aim to help clients with top-notch services to study compounds, including small molecules, active pharmaceutical ingredients (API), natural products, polymers, and biomolecules, including proteins, carbohydrates, and nucleic acids. We are equipped with the latest technology and equipment to perform 1D heteronuclear experiments, advanced 1D and 2D analysis, quantitative NMR (Q-NMR), high resolution and high sensitivity NMR, No-D NMR, and much more. We offer customized solutions that cater to your unique research needs.

Read:- Mass Spectrometry & Its Importance for the Analysis & Discovery of Active Molecules in Natural Products

Why do purity enrichment services matter in Pharmaceutical Manufacturing?

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In pharmaceutical manufacturing, the importance of high-purity components cannot be overstated. The presence of impurities, especially API-related impurities, can impact the quality, safety, and efficacy of the drugs. The presence of even small amounts of unwanted components can influence the effectiveness and safety of pharmaceutical products. Analytical methods can easily accurately measure the levels of chemical impurities. Methods like mass spectroscopy and gas chromatography detect the presence of impurities and identify the amounts. 

Understanding Pharmaceutical Impurities 

Pharmaceutical impurities are unwanted chemicals in API (active pharmaceutical ingredients) or drug formulations. These impurities can arise in synthesis or from other sources like reagents, solvents, catalysts, or reactions from by-products. This is why identification, quantification, and control of impurities are crucial. 

Purity Enrichment Services in Pharmaceutical Manufacturing 

Aral Research offers purity enrichment services for pharmaceutical manufacturing and biologics development. We provide flash chromatography and HPLC service in Ahmedabad to isolate and purify specific compounds from complex mixtures. Our analytical team leverages the latest technology and methodology to perform product characterization and analytical testing to support drug discovery and formulation. 

  • Preparative Liquid Chromatography: Since the impurities in the drug are present in low quantity, detailed analysis can be done using isolation of impurities. Preparative LC helps to isolate impurities in adequate amounts. 
  • LCMS: LCMS is a highly sensitive and specific analytical tool that is used to detect, identify, and quantify product impurities. Our LCMS analysis in Ahmedabad allows for the unambiguous identification of unknown traces of impurities. 
  • Gas Chromatography: GC is a standard analytical tool for the analysis of volatile organic impurities. A combination of GC and mass analysis can be used to identify and quantify residual solvents. 

Benefits of Purity Enrichment Services for Pharmaceutical Manufacturing 

  • Enhance Product Quality: Ensure your products are free from impurities and contaminants and meet quality standards. 
  • Regulatory Compliance: Our purity enrichment services ensure pharmaceutical companies meet regulatory requirements. 
  • Safety & Efficacy: Ensures the drugs are of precise quality and safe from usage. 
  • Consistent Quality: We help contribute to consistency in all batches to maintain drug efficiency. 

At Aral Research, we specialize in providing qualitative analytical data with precise interpretation to help clients with research requirements. So whether you are looking for mass analysis, LCMS analysis, lyophilisation, or HPLC/UPLC, we’ve got you covered! Call us to discuss your research requirements. 

The Science Behind Lyophilisation: How It Preserves Your Products?

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Pharmaceutical manufacturing relies on consistent efficacy and extended shelf life. Lyophilization or freeze-drying plays a pivotal role in helping achieve these goals. It is a critical process that involves freezing a substance while minimising the pressure to allow frozen water to be sublime from solid to water vapour to the gas phase. Let’s understand the science behind lyophilisation and how it can preserve your pharmaceutical products. 

What is Lyophilisation? 

Lyophilisation is a water-removal process that is used to preserve perishable components and materials. This process helps to prolong the shelf life of pharmaceuticals and make them convenient for transportation. Lyophilisation works basically by freezing the sample of interest, then minimising the pressure and adding heat for the frozen water in the sample to sublimate from solid to water vapour to gas.  Aral Research provides high-quality lyophilisation services in Ahmedabad. We have extensive experience in the development and optimisation of lyophilisation to ensure seamless scale-up of your products. 

How Does Lyophilisation Work? 

Lyophilisation or freeze drying is a 3-stage process that includes freezing, sublimation, and adsorption phases to preserve products. Lyophilised products reduce storage and shipping costs, along with longer shelf life, resulting in less waste. This process occurs in three stages: 

Freezing Stage 

There are different techniques to freeze the product, such as freezers, shell freezers or a freeze dryer. The material is frozen below the triple point to ensure sublimation and rapid melting to preserve its physical form. Lyophilisation makes this easier through large ice crystals that are formed by slow freezing. It is important to note that in the case of biological materials, crystals may be too large, and they can break the cell walls, leading to undesired freezing drying results. To avoid this, the freezing needs to be done quickly. For materials that are prone to precipitate, annealing should be used. 

Sublimation Stage (Primary Drying)

The second stage of lyophilisation is the sublimation phase. In this, the pressure is lowered, and the material is heated for the water to sublimate. The cold condenser offers a surface for the water vapour to solidify and protect the vacuum pump from the water vapour. In the primary drying stage, nearly 95% of water is removed from the product. 

Adsorption  Stage (Secondary Drying)

In the final stage of lyophilisation viz the adsorption phase, the ionically-bound water molecules are removed by increasing the temperature. This phase ensures the achievement of the perfect moisture content while focusing on the stability and preservation of the lyophilised product. 

Expert Lyophilisation Services 

At Aral Research, we ensure careful monitoring, temperature control, and pressure control for precise stability and quality of the final product. We use advanced equipment and technology to develop and optimise lyophilisation cycles in our analytical lab to allow you to scale up commercial production seamlessly. Our team is well-equipped to provide custom lyophilisation formulations for proteins, anti-biotics, small molecules, and other combination products.

Moreover, as a leading research and analytical lab, we also provide LCMS service in Ahmedabad. Aral Research is your one-stop destination for all your analytical needs. To discuss your lyophilisation project needs, get in touch with us today. 

Purification and Isolation Services: Ensuring Precision in Research and Production

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Purification and isolation services focus on different analytical methods to ensure the precision and accuracy of components used in research and production. They are crucial to achieving reliable results in scientific research and high-quality outcomes. Our purification and isolation of high-purity compounds from complex matrices facilitate development, research, and other commercial applications. Aral Research uses the latest techniques like preparative HPLC, flash chromatography, and liquid-liquid extraction to purify and isolate specific components. 

Analytical Techniques for Purification and Isolation  

Preparative HPLC

Preparative HPLC (high-performance liquid chromatography) focuses on the isolation of components at the molecular level. The primary goal of this analytical technique is to isolate and purify a significant amount of compounds from the sample of interest. At Aral Research, our purification and isolation service in Ahmedabad focuses on using preparative HPLC combined with other technology for highly efficient and reliable compound separation. This helps in quality control, ensuring the end products meet the standards. 

Flash Chromatography

Flash chromatography is a chemical separation method for purification. The working principle of flash chromatography relies on the innate partitioning behavior between the mobile phase and the stationary phase to separate specific components of a mixture. 

Liquid-liquid Extraction

The liquid-liquid extraction is a technique used for purification that involves the transfer of a solute from a liquid phase to the organic or aqueous phase. 

Get End-to-End Analytical Support & Assistance 

At Aral Research, we are equipped with cutting-edge technology for high-purification processes, including LCMS and preparative HPLC service in Ahmedabad. We specialize in the isolation, purification, and characterization of unknown impurities in various components. At our state-of-the-art analytical lab, we provide end-to-end services, from initial isolation to purification and detailed characterization. Our years of commitment to providing comprehensive and reliable impurity standards have helped researchers and manufacturers achieve precision in production and meet the rigorous demands of industry regulations. Partner with us for isolation & purification and experience high-quality purified compounds. 

Nuclear Magnetic Resonance (NMR): A Critical Tool For Molecular Characterization

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Nuclear Magnetic Resonance (NMR) is an analytical method that is used to determine the molecular structure of the sample of interest. NMR spectrometry uses the magnetic characteristics of specific nuclei. It is a critical tool for the identification of the physical and chemical properties of atoms and molecules. Let’s understand NMR spectrometry for molecular characterization in different fields. 

What is Nuclear Magnetic Resonance (NMR)? 

NMR is an advanced analytical technology that allows researchers to study the unique physical, chemical, and biological characteristics of a molecule structure. It is based on the interaction of externally applied radiofrequency radiation with atomic nuclei. In this interaction, there is an exchange of energy that leads to a change of an intrinsic property of the atomic nuclei known as the ‘nuclear spin’. It is particularly useful in the analysis of pharmaceuticals, drug discovery and development, and screening of weak-binding compounds. Aral Research offers high-quality NMR services in Ahmedabad. We strive to provide detailed molecular information with high-field NMR data for clients in the science and pharmaceutical industry. 

NMR Analysis is Used for: 

  • Characterise the molecular structures
  • Research and study molecular dynamics & interactions
  • Quantify known and unknown components 
  • Inspect the composition of mixtures 
  • Chemical structure analysis of liquids & dissolved salts
  • Quantification of mixture components 
  • Characterisation of polymers (structure, end-groups & average molecular weight)
  • Deformulation of products 

Working Principle of Nuclear Magnetic Resonance (NMR) Analysis 

  • The working principle behind NMR is that many nuclei spin and all are electrically charged. When an external magnetic field is applied, there is a possibility of energy transfer between the base energy and high energy level. 
  • This energy transfer occurs at a wavelength that corresponds to the radio frequency. Further, when the spin comes to its base energy, it is emitted at a similar frequency. 
  • The signal matches the transfer and is measured in various ways and processed to obtain an NMR spectrum for a specific nucleus. 

At Aral Research, we offer a comprehensive range of analytical services, including mass analysis, LCMS analysis, NMR analysis, lyophilisation, and much more. Our nuclear magnetic resonance service is tailored to meet your specific analytical needs. We can perform 1D heteronuclear experiments, advanced 1D & 2D analysis, quantitative NMR, high resolution & highly sensitive NMR, No-D NMR, and identification of impurities & unknown. For more information, call us today. 

Mass Spectrometry & Its Importance for the Analysis & Discovery of Active Molecules in Natural Products

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Mass spectrometry (MS analysis) is considered the best method for analyzing a molecule’s structure. MS analysis offers details about a compound’s molecular weight and presents the atomic mass units and 10000 atomic mass units, depending on the accuracy of the mass analyzer. Additionally, mass spectrometry provides information related to analyzing compounds from natural products. In this blog, we discuss mass spectrometry and its importance for the analysis and discovery of active molecules in natural products.

Role of MS in Analysis & Discovery of Active Molecules in Natural Products

The development of mass spectrometry, along with research, has proven to be game-changing in enhancing the ionization process and ion analysis. Mass spectrometry has significantly contributed to qualitative control of natural products and to identifying new metabolites. Natural products consist of a mixture of complex quantity components. In the field of natural products, various studies regarding secondary metabolites have been validated through mass analysis.

Mass Spectrometry and Natural Products

The success of mass spectrometry over the years, along with variability methods and instruments, allows all molecules of natural products to be analyzed quantitatively and qualitatively. 

  • Essential Oils: These oils are basically volatile metabolites, so the study and research are straightforward. Mass spectrometry allows the investigation of molecules that form these natural products. 
  • Fatty Acid: Many plant specimens are composed of saturated and unsaturated fatty acids. Mass spectrometry, along with chemical derivational techniques, is used for research purposes to form ethyl ester and methyl.  
  • Aromas & Flavours: The odour and flavour of fruits and vegetables are vital to distinguishing their taste and texture. Mass spectrometry is crucial to identifying the chemistry of these components. Many of these molecules are volatile and hence impossible to remove in the vapour stream. They are removed with non-polar solvents to introduce them to the chromatographic system. 
  • Alkaloids: These are active ingredients that contain nitrogen in their structural features. Some alkaloids, such as nicotine, caffeine, and xanthine alkaloids, are directly analyzed by mass spectrometry, while others, with high volatility, need separation in gas chromatography. 

Mass spectrometry analyzes natural products. Its high sensitivity and detailed structural information make mass analysis indispensable in research and development laboratories. Aral Research offers high-quality mass spectrometry analysis services. We ensure high-quality mass analysis data with a WATERS SDQ detector and TQD detector equipped with Electrospray ionization (ESI) and Atmospheric-pressure Chemical Ionization (APCI) mode detection. We serve many industries, including proteomics, forensics, metabolomics, and life science. We can help you solve analytical problems and research goals.

 

Advancements in LCMS Technology: Transforming Pharmaceutical Analysis

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In the constantly changing analytical chemistry and research field, there is a demand for more precise and reliable analytical methods. Liquid chromatography-mass spectrometry (LC-MS) has proven to be a vital methodology that has transformed life science and related fields. LC-MS analysis plays a pivotal role in pharmaceutical development and formulation. In this blog, we delve into the advancements in LC-MS Technology and how they have revolutionized the pharmaceutical field.

Understanding LC-MS and Its Principle

LC-MS technology involves an HPLC where individual components of a mixture are first separated, which is followed by ionization and separation of ions on the basis of their mass/charge ratio. The separated ions are later directed to a photo or electric multiple-tube detector that identifies and quantifies every ion. The ion source is a vital component in MS analysis as it helps precisely generate ions for analysis. The ion source can be Electrospray Ionization (ESI) or Atmospheric Pressure Chemical Ionization (APCI) for ionizing intact molecules. LCMS analysis together provides a robust solution for analyzing complex mixtures in pharmaceutical products.

Application of LC-MS in Pharmaceutical Analysis

LC-MS Technology is a comprehensive tool for various challenges faced in pharmaceutical research and development. It offers a reliable, versatile, and robust platform for gaining critical data at every stage of drug development.

LC-MS Application Across Drug Development Stages in Pharmaceutical

Stage 1: Discovery of the drug candidate 

  • Quick LC-MS for monitoring target drug candidate
  • High-resolution MS analysis for structural proof.
  • Vitro pharmacokinetic & metabolic research 

Stage 2: Chemical drug development & scale-up

  • Structural confirmation of initial material, intermediaries, and final target drug candidate. 
  • Evaluating impurity profiles in every batch
  • Characterisation and qualification of drug substances

Stage 3: Stability Testing 

  • Monitoring variation in impurity profiles. 
  • Analyzing compatibility within drug compounds, formulation excipients, and packaging material. 
  • Analyzing intrinsic stability and degradation pathways
  • Examination of chromatographic peak purity 
  • Developing  impurity profiles under a stressed condition

Stage 4: Drug Metabolites, Pharmacokinetic and Toxicological Studies

  • Identifying drug metabolites under physiological conditions
  • Quantitation of drug substances and metabolites in biological mixture
  • Monitoring impurity profiles 
  • Ongoing examination of impurity profiles on drug products and substances under long storage conditions.

Recent Advancement in LC-MS

Hardware Enhancements: 

  • Improved ionization methods
  • Enhanced system efficiency
  • More sensitive detectors

New Ionization Techniques: 

  • Electrospray Ionization Inlet (ESII): This is a sophisticated technique that applies high voltage to a metal union, which connects tubing from a solvent delivery system to a piece of fused silica tubing that is put into the heated inlet tube of a mass spectrometer. 
  • Uni-spray: It takes advantage of the vortex and Coanda effect to form droplet break-up and dissolvation.

Improved Sensitivity and Resolution 

Another remarkable advancement in LC-MS Technology is the enhancement in resolution and sensitivity. The more advanced models are more versatile and detect even traces of compounds, which is valuable in identifying unknown impurities. 

Software Enhancement 

Aral Research is a renowned LCMS analysis service lab equipped with the latest LC-MS systems, which feature real-time analysis, cloud storage, and automation. The advanced algorithms are ideal for complex samples and offer easy integration and precise results. 

Conclusion

The LC-MS technology constantly evolves to cater to the diverse development and research requirements. Not just the pharmaceutical, but LC-MS plays a pivotal role in the life science field. Aral Research is a leading liquid chromatography-mass spectrometry lab in India that has hands-on experience with approved and novel drugs. With high sensitivity, high qualitative capability, and high detection selectively, our LCMS services focus on the flexibility of simultaneous multi-component analysis. We can help solve complex analytical questions with forefront analytical techniques.

 

 

 

How can Mass Spectrometry be used to Identify Unknown Compounds?

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Mass spectrometry is an instrumental analytical technique to measure the mass-to-charge ratio of one or more molecules present in a sample of interest. It is a powerful analytical tool to quantify unknown materials and identify unknown compounds and structural and chemical properties of different molecules.

Working Principle of Mass Spectrometry Can Be Used to Identify Unknown Compound

Mass spectrometry, with its ability to measure the mass-to-charge ratio (m/z) and calculate the exact molecular weight of sample components, is a versatile tool. It identifies unknown compounds through molecular weight determination, quantifies familiar compounds, and determines structure and chemical properties. It essentially studies the effects of ionizing energy on molecules, generating multiple ions from the sample, then separating them according to their specific mass-to-charge ratio (m/z), and noting the related abundance of each type of ion. This versatility makes it an intriguing field of study.

Component of Mass Spectrometry

  • Ionization source
  • Mass analyzer
  • Ion detection system

Here is How Mass Spectrometry Can Be Used to Identify Unknown Compound

  • Ionization Source: At first, the molecules are converted to gas-phase ions to move them and are manipulated by external electric and magnetic fields. The molecular ions undergo fermentation, and each primary product derived from the molecular ion also undergoes fermentation. 
  • Mass Analyzer: After ionizing, the ions are sorted and separated based on mass-to-charge (m/z) ratios and detected proportionally to their abundance. 
  • Ion Detection System: The separated ions are later measured and out through a data system where the mass-to-charge ratio is stored together with its relative abundance. A mass spectrum of the molecule displays the result in the form of a plot of ion abundance Vs. m/z ratio. The ions offer information about the precursor molecule’s nature and structure. In the mass spectrum, in the case of a pure compound, if a molecule ion is present, it appears at the highest value of m/z, later followed by ions consisting of heavier isotopes, and gives the compound’s molecular mass.

Aral Research is a full-fledged research lab specializing in custom analytical services for complex compounds. We aim to provide researchers with modern techniques and equipment to characterize biomolecules. We are equipped with the latest mass spectrometry equipped backed with Electrospray Ionization (ESI) and Atomspheric-pressure Chemical Ionization (APCI) mode detection. Contact us to discuss your requirements.

How is HPLC Used in the Medical Sector?

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High-performance liquid Chromatography (HPLC) is a highly useful analytical method with many applications. It is used to analyze drugs and medicines for purity, ensuring the highest standards of pharmaceutical products. HPLC is also used for research and diagnosis purposes.

Role of High Performance Liquid Chromatography in Medical Research

Pharmaceuticals, such as medications and drugs used to treat and cure illness and disorder, require no room for risk. HPLC services are renowned for their unparalleled precision and accuracy in the identification and quantification needed for pharmaceuticals.  Its applications include separating and identifying drug compounds and their metabolites, making HPLC indispensable in formulation development and process validation. High-performance liquid chromatography is also employed for stability testing, determining the degradation of pharmaceuticals over time and under different conditions. Aral Research offers HPLC to test drug formulation for stability, concentration, homogeneity, and purity. Our purity by HPLC services make it a staple in the medical industry, facilitate development and quality control, and adhere to standards in pharmaceutical manufacturing.

Application of HPLC in the Medical Sector

High-performance liquid chromatography is a versatile technique in the medical sector with various applications to ensure the safety and effectiveness of drugs.

  • Purity Analysis: HPLC is used to verify the purity of drugs by identifying and quantifying impurities and degradation products to ensure the safety of pharmaceuticals. 
  • Stability Studies: It allows drug stability tests under varying conditions, such as humidity, light, and temperature, to determine the expiry date and how it needs to be stored.
  • Quantitative Analysis: HPLC helps accurately measure API (active pharmaceutical ingredients) in drug formulation to ensure precise dosage.
  • Separation Purposes: HPLC separates complex mixtures along with mixtures with the same chemical properties to help research and manufacture complex drugs, such as multi-drug combinations. 
  • Quality Control: HPLC testing services ensure consistency in manufacturing and adherence to quality parameters.

High-performance liquid chromatography’s versatility, accuracy, and efficacy make it indispensable in the medical, pharmaceutical, and life science industries. At Aral Research, we ensure the efficiency, accuracy, and reliability of HPLC systems to ensure high standards. We offer customized solutions, quick turnaround time, and accuracy to meet your analytical goals. Call us to discuss your analytical and research requirements.

Difference Between HPLC and UPLC

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High performance liquid chromatography (HPLC) and ultra performance liquid chromatography (UPLC) are common techniques used in analytical laboratories to separate components. HPLC and UPLC separate different components found in mixtures by utilizing high pressure to drive solvents through columns. Despite its common purpose, there are some differences between both. In this blog, we explore the difference between HPLC and UPLC, shedding light on its importance in the analytical field. 

HPLC Vs UPLC: What are the Similarty in HPLC and UPLC? 

Both these methods are used to separate components found within a mixture. These liquid chromatography methods use liquid solvents in the mobile phase. They are employed to identify and quantify components. 

What is the Difference Between HPLC and UPLC? 

Here are some of the major difference between HPLC and UPLC: 

  • Pressure: The key difference between HPLC and UPLC is the pressure it can withstand. Earlier known as high-pressure liquid chromatography, it can withstand pressure up to 6,000 psi, while UPLC can withstand pressure upto 15,000 psi. 
  • Particle Size: Along with high pressure levels, UPLC also has a higher sensitivity. This means it allows a lower particle size within the columns, making it ideal for low-component analysis. 
  • Applications: Due to its high sensitivity, ultra performance liquid chromatography is used for dietary supplements and biological samples that have low quantities of different components. At the same time, HPLC is employed in applications like water purification and the identification of impurities in pharmaceuticals. 
  • Flow Rate: UPLC uses a higher flow rate than HPLC due to its small particle size and higher pressure.
  • Sensitivity and Resolution: UPLC’s smaller particle size and less band broadening provide higher sensitivity and superior resolution. 

Conclusion 

High performance liquid chromatography and ultra performance liquid chromatography are advanced analytical methods used to separate and evaluate components of different mixtures. Aral Research offers UPLC and HPLC analysis services to life science and pharmaceutical fields. Our experienced team is well-equipped to develop the HPLC method for chiral and achiral molecules. We provide customized solutions, quick turnaround time, and competitive pricing to support and meet analytical goals. Call us to discuss your requirements.

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